Introduction Amitriptyline is a tricyclic antidepressant (TCA) primarily used in the management of major depressive disorder, neuropathic pain, migraine prophylaxis, and insomnia. Mechanism of Action of Amitriptyline involves inhibition of serotonin (5-HT) and norepinephrine (NE) reuptake at presynaptic nerve terminals, thereby increasing their synaptic concentrations. Additionally, it. Amitriptyline, formerly sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [11] Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line therapy for these indications. Description Amitriptyline is used to treat symptoms of depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. This medicine is a tricyclic antidepressant (TCA). This medicine is available only with your doctor's prescription. Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. Amitriptyline is a tricyclic antidepressant used to treat depression and, off-label, conditions like insomnia, anxiety, migraines, and chronic pain. Detailed Amitriptyline dosage information for adults, the elderly and children. Includes dosages for Depression; plus renal, liver and dialysis adjustments. NHS medicines information on amitriptyline – what it's used for, side effects, dosage and who can take it. Amitriptyline belongs to a group of medicines known as tricyclic antidepressants. It is used for nerve pain, preventing migraines, and bedwetting in children. Amitriptyline is a medication that treats depression. It increases the amount of serotonin and norepinephrine in your brain. Find patient medical information for Amitriptyline (Amitid, Elavil, Endep) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.